The Tonight Show with Conan O'Brien kicks it off with actor/comedian Will Ferrell and musical guest Pearl Jam.

The Tonight Show with Conan O'Brien welcomes actor Tom Hanks and musical guest Green Day.

The Tonight Show with Conan O'Brien welcomes actress Julia Louis-Dreyfus, actor Bradley Cooper and musical guest Sheryl Crow.

The Tonight Show with Conan O'Brien welcomes actress Gwyneth Paltrow, The Soup host Joel McHale and musical guest John Mayer Trio.

The Tonight Show with Conan O'Brien welcomes Ryan Seacrest, comedian Patton Oswalt and musical guests Chickenfoot.

The Tonight Show with Conan O'Brien welcomes actor David Duchovny and Anna Friel. Comedian Bill Burr performs.

The Tonight Show with Conan O'Brien welcomes actor Eddie Murphy, Angela Kinsey and musical guest Bonnie Raitt & Taj Mahal.

The Tonight Show with Conan O'Brien welcomes comedian Dane Cook, Steven Ho and musical guest Rancid.

The Tonight Show welcomes comedian Norm MacDonald, comedian Jim Gaffigan and musical guest Neko Case.

The Tonight Show with Conan O'Brien welcomes actor/singer Jamie Foxx and comedian Kevin Nealon. Music performed by Jamie Foxx.

The Tonight Show with Conan O'Brien welcomes Dodgers manager Joe Torre, actor Will Arnett and musical guest Spinal Tap.

The Tonight Show with Conan O'Brien welcomes actor/writer Larry David, Lauren Conrad and musical guest Gavin Rossdale.

The Tonight Show with Conan O'Brien welcomes basketball star Kobe Bryant, actor William Shatner and musical guests Incubus.

The Tonight Show with Conan O'Brien welcomes guests Eva Mendes, Christopher Mintz-Plasse and musical guests The Dead Weather.

The Tonight Show with Conan O'Brien welcomes actor Shia LaBeouf, L.A. Lakers' coach Phil Jackson and musical guest Holly Williams. Triumph, The...

The Tonight Show with Conan O'Brien welcomes guests Cameron Diaz, Johnny Strange and musical guest Pete Yorn.

The Tonight Show with Conan O'Brien welcomes guests Lisa Kudrow, Billy Mays & Anthony Sullivan and musical guest Elvis Costello.

The Tonight Show with Conan O'Brien welcomes guests Brandon McMillon, Kerry Washington and musical guests Wilco.

The Tonight Show with Conan O'Brien welcomes guests Bruno, Stephen Moyer and a closing performance by Cirque du Soleil Zumanity.

The Tonight Show with Conan O'Brien welcomes guests Snoop Dogg, Jerry Ferrara and musical guest Adele.

The Tonight Show with Conan O'Brien welcomes actor/game show host Howie Mandel, singer Alanis Morissette, and musical performance by Death Cab for...

The Tonight Show with Conan O'Brien welcomes as guests actor Samuel L. Jackson, actor Kevin Connolly and musical guest Andrew Bird.

The Tonight Show with Conan O'Brien welcomes as guests from the The Today Show Meredith Vieira, from Deadliest Catch Captain Andy Hillstrand and a...

The Tonight Show with Conan O'Brien welcomes legendary TV host Larry King, actress Zooey Deschanel and musical guests Playing For Change.

The Tonight Show with Conan O'Brien welcomes comedy great Bob Newhart, from So You Think You Can Dance TV show host Cat Deeley and musical guest Ray...

The Tonight Show with Conan O'Brien welcomes guest actor from Law & Order: Criminal Intent Jeff Goldblum, comedian Bill Engvall, and a performance by...

The Tonight Show with Conan O'Brien welcomes swimming champion Michael Phelps, actress Paget Brewster and musical guests Sugar Ray.

The Tonight Show with Conan O'Brien welcomes actor Dana Carvey, Anthony Anderson and musical performance by Allison Iraheta.

The Tonight Show with Conan O'Brien welcomes actor Gerard Butler, tennis player Venus Williams and musical performance by Daughtry.

The Tonight Show with Conan O'Brien welcomes guest actor Seth Green, Steven Ho and musical guest Demi Lovato.

The Tonight Show with Conan O'Brien welcomes guest actors Adam Sandler, Peter Sarsgaard and musical guest Kate Voegele.

The Tonight Show with Conan O'Brien welcomes guest actor Jonah Hill, actress Cheryl Hines, and comic Dan Naturman.

The Tonight Show with Conan O'Brien welcomes guest actors James Spader and Jack McBrayer and musical guest Mat Kearney.

The Tonight Show with Conan O'Brien welcomes comedian Zach Galifianakis, actress Keke Palmer and musical guest Jason Aldean.

The Tonight Show with Conan O'Brien welcomes actor Seth Rogen, actress Rose Byrne, and musical guest Eric Hutchinson.

The Tonight Show with Conan O'Brien welcomes actress Meryl Streep, film director/producer/writer Judd Apatow and musical guests The Fray.

The Tonight Show with Conan O'Brien welcomes supermodel Heidi Klum, actor Steve Zahn and British comedian Jimmy Carr.

The Tonight Show with Conan O'Brien welcomes actor Rainn Wilson, radio personality Rachel Maddow and musical guests Chicago.

The Tonight Show with Conan O'Brien welcomes Jack Dagger & Tonya Kay, actor Paul Giamatti and musical guest Regina Spektor.

The Tonight Show with Conan O'Brien welcomes actor Hank Azaria, host of "Man v. Food" Adam Richman and musical guest Ben Harper and the Relentless...

The Tonight Show with Conan O'Brien welcomes actor Ashton Kutcher, actress Charlyne Yi, and musical guest Gomez.

The Tonight Show with Conan O'Brien welcomes actor Jeremy Piven, The Human Cannonballs and musical guests the All-American Rejects.

The Tonight Show with Conan O'Brien welcomes actress Sienna Miller, actor and TV show host Steve Schirripa, and a performance by comic Deon Cole.

The Tonight Show with Conan O'Brien welcomes actor Ed Helms and The Jonas Brothers. Both Ed Helms and The Jonas Brothers perform. Also, Conan and...

The Tonight Show with Conan O'Brien welcomes Eric Bana, Mary Lynn Rajskub and musical guest Flo Rida.

The Tonight Show with Conan O'Brien welcomes Kyra Sedgwick, Hugh Dancy and musical guest Lyle Lovett and His Large Band.

The Tonight Show with Conan O'Brien welcomes actor Jon Hamm, freestyle motocross athletes Robbie Maddison, Adam Jones and Mike Mason. Musical guests...

The Tonight Show with Conan O'Brien welcomes Chef/TV host Gordon Ramsay, actor BJ Novak and micro sculptor Willard Wigan.

The Tonight Show with Conan O'Brien welcomes Robin Williams, Piers Morgan and musical guests All Time Low.

The Tonight Show with Conan O'Brien welcomes NBA superstar Shaquille O'Neil, comic Demitri Martin, and musical performance by Jack Ingram.

The Tonight Show with Conan O'Brien welcomes TV host Bill Maher, TV host Nick Cannon and musical guests Kings Of Leon. Also, Conan and Andy take a...

The Tonight Show with Conan O'Brien welcomes film director Quentin Tarantino, actor Mark Feuerstein and musical guest Smokey Robinson. Conan takes a...

The Tonight Show with Conan O'Brien welcomes actor Bradley Cooper, actor/comedian Jon Lovitz and musical guests Franz Ferdinand. Plus, Conan's...

The Tonight Show with Conan O'Brien welcomes boxing legend Mike Tyson, mentalist Keith Barry and musical guest Matisyahu. Plus, The Tonight Show...

The Tonight Show with Conan O'Brien welcomes reptile expert Nigel Marven, actor DJ Qualls and musical guest Colbie Caillat. Also, a new The Tonight...

The Tonight Show with Conan O'Brien welcomes comedian Norm MacDonald, actor Thomas Haden Church and musical guest Pitbull. Also, Conan brings back...

The Tonight Show with Conan O'Brien welcomes actor Elijah Wood, actress Mila Kunis, and musical guests Cheap Trick.

The Tonight Show with Conan O'Brien welcomes Senator John McCain, comedian Frank Caliendo, and musical guest Third Eye Blind. Conan debuts Hangin'...

The Tonight Show with Conan O'Brien welcomes actress Sandra Bullock, Little League All-Stars from Chula Vista Park View, and comedian Gina Yashere.

The Tonight Show with Conan O'Brien welcomes actress Jennifer Connelly, actor/comedian Zane Lamprey, and musical guest Ziggy Marley. Plus, the grand...

The Tonight Show with Conan O'Brien welcomes actress Kate Beckinsale, comic/actor Richard Lewis, and guest Dhani Harrison introducing The Beatles -...

The Tonight Show with Conan O'Brien welcomes actor Tom Arnold, comedian Tim Meadows and musical guest Reba McEntire.

The Tonight Show with Conan O'Brien welcomes actor Dennis Quaid, crossbow marksmen Mr. and Mrs. G, and musical guest Paolo Nutini. Also, Conan...

The Tonight Show with Conan O'Brien welcomes actor Antonio Banderas, actor Bill Hader, and musical guest Chris Cornell. Plus, a new installment of...

The Tonight Show with Conan O'Brien welcomes actress Charlize Theron, stuntman Steven Ho, and musical performance by Dave Matthews Band. Plus,...

The Tonight Show with Conan O'Brien welcomes actress Jennifer Aniston, tennis player Melanie Oudin, and musical performance by Phoenix. Plus, Conan...

The Tonight Show with Conan O'Brien welcomes actor Aaron Eckhart, former professional football player Michael Strahan, and musical guests Yeah Yeah...

The Tonight Show with Conan O'Brien welcomes actress Megan Fox, comedian Louis C.K. (who also performs) and musical guest Kevin Skinner, the winner...

The Tonight Show with Conan O'Brien welcomes actress Courteney Cox, actor Ted Danson, and musical performance by Nelly Furtado. Special appearance by...

The Tonight Show with Conan O'Brien welcomes actor/comedian Ricky Gervais, fried-food innovator "Chicken" Charlie Boghosian, and musical guests...

The Tonight Show with Conan O'Brien welcomes actress Rebecca Romijn, comedian Lisa Lampanelli and musical guests Monsters of Folk. Plus, Conan and...

The Tonight Show with Conan O'Brien welcomes actor Martin Short, fashion consultant Tim Gunn and musical guest Wynonna. Also, Conan takes a look at...

The Tonight Show welcomes animal expert Dave Salmoni, actor/presenter Joel McHale, and musical guest India Arie. Also, a new Tonight Show segment:...

The Tonight Show welcomes actress Drew Barrymore, jockey Joe Talamo and musical guests Paramore. Plus, Conan and Andy take a look and share what...

The Tonight Show welcomes actor John Krasinski, comedian Patton Oswalt and comedian Quinn Dahle. Also, the Hunky Vampire returns and new Celebrity...

The Tonight Show welcomes actress Kate Walsh, actor Jesse Eisenberg and musical guest Brad Paisley. Also, back row appreciation with the Tonight Show...

The Tonight Show welcomes director Michael Moore, animated series creator Seth MacFarlane and musical guests Rodrigo Y Gabriela. Plus, Conan visits...

The Tonight Show welcomes game show host Drew Carey, sportscaster Joe Buck, and musical guest Joshua Bell with Tiempo Libre. Plus, Conan replies yet...

The Tonight Show welcomes actress Ellen Page, comedian Kevin Nealon, and musical guest Dierks Bentley. Plus, Conan answers Newark's Mayor Corey...

The Tonight Show with Conan O'Brien welcomes actor Edward Norton, actress Kristen Bell and musical guest Anvil. Also, a new installment of In The...

The Tonight Show with Conan O'Brien welcomes actor Jason Bateman, actress Selena Gomez and musical guest Toby Keith. Also, following their ongoing...

The Tonight Show with Conan O'Brien welcomes actor Christian Slater, NASCAR driver Jimmie Johnson, and musical guests Backstreet Boys. Also, someone...

The Tonight Show with Conan O'Brien welcomes comic actor Jeff Garlin, baseball snagger extraordinaire Zack Hample and musical guests Lady Antebellum....

The Tonight Show with Conan O'Brien welcomes actor Jamie Foxx, actor Jason Alexander, and performance by Grizzly Bear.

The Tonight Show welcomes guests actor Ice-T, actor Eddie Izzard and musical guests Flaming Lips. Also, Conan shows a product he's finally proud of...

The Tonight Show welcomes guest tennis player Serena Williams, actor Ken Jeong and musical guests Rascal Flatts. Also, new Celebrity Surveys!

The Tonight Show welcomes actor John C. Reilly, Dr. Sanjay Gupta and comedian Matt Braunger. Plus, the day before receiving Mayor Corey Booker as a...

The Tonight Show welcomes Newark Mayor Cory Booker, actor Max Records and musical guests Dashboard Confessional. Plus, Triumph the Insult Comic Dog...

The Tonight Show with Conan O'Brien welcomes comic Kathy Griffin, Captain Chesley Sullenberger and musical guests Wolfmother. Plus, another...

The Tonight Show with Conan O'Brien welcomes guest actor Garry Shandling, chef Paula Deen, and musical guests Julian Casablancas.

The Tonight Show with Conan O'Brien welcomes guests actor Chris O'Donnell, ski racer Lindsey Vonn, and musical performance by Uncle Kracker.

The Tonight Show with Conan O'Brien welcomes guests actor Denis Leary, bat expert Rob Mies, and musical performance by The Swell Season. Also, Conan...

The Tonight Show with Conan O'Brien welcomes guests actor Ewan McGregor, snowboarder Shaun White, and a musical performance by Tegan & Sara. Plus, a...

The Tonight Show with Conan O'Brien welcomes guests actor Ewan McGregor, snowboarder Shaun White, and a musical performance by Tegan & Sara. Plus, a...

The Tonight Show with Conan O'Brien welcomes guests actor Neil Patrick Harris, TV personality Paul Teutul Sr., and a musical performance by Creed....

The Tonight Show with Conan O'Brien welcomes guest actress Amy Poehler, NBA Hall of Famers Magic Johnson and Larry Bird and musical guests The...

The Tonight Show with Conan O'Brien welcomes guests actor Jim Carrey, actress Olivia Wilde, and a musical performance by Zack Brown Band. Plus, Conan...

The Tonight Show with Conan O'Brien welcomes actor Cory Monteith, comedian Harland Williams and musical guests Pixies. Also, Mark Pender faces off...

The Tonight Show with Conan O'Brien welcomes actor Kelsey Grammer, Major Brian Dennis and his Iraqi dog of war Nubs, and musical guest David Gray....

The Tonight Show with Conan O'Brien welcomes actress Jessica Biel, comic Bob Einstein as Super Dave Osborne and musical guest John Fogerty. Also, a...

The Tonight Show with Conan O'Brien welcomes actress Heather Locklear, Dr. Drew Pinsky, and comedian guest Rodman. Also, a new episode of Noches de...

The Tonight Show with Conan O'Brien welcomes former Vice President Al Gore, actor Jim Parsons, and musical guest Jason Mraz. Plus, Conan and Andy...

The Tonight Show with Conan O'Brien welcomes actress Reese Witherspoon, actress Gabourey Sidibe, and a musical performance by Kris Allen. Also, Conan...

The Tonight Show with Conan O'Brien welcomes actress Kristen Stewart, director Judd Apatow and musical guest Carrie Underwood.

The Tonight Show with Conan O'Brien welcomes actress Jane Lynch and musical guest 50 Cent.

The Tonight Show with Conan O'Brien welcomes actor Seth Green, TV personalities Heidi Montag and Spencer Pratt and musical guests Brian Setzer...

The Tonight Show with Conan O'Brien welcomes actress Nicole Kidman, journalist Anderson Cooper and musical guest Leona Lewis.

The Tonight Show with Conan O'Brien welcomes actress Eva Mendes, musician Jon Bon Jovi and musical guests Bon Jovi.

The Tonight Show with Conan O'Brien welcomes actor Taylor Lautner, actor John Lovitz and musical guests Timbaland with Nelly Furtado and SoShy.

The Tonight Show with Conan O'Brien welcomes actor Jack McBrayer, model Marisa Miller, and a musical performance by Weezer.

The Tonight Show with Conan O'Brien welcomes actor Norm MacDonald, snowboarder Gretchen Bleiler and comic Dan Cummins.

The Tonight Show with Conan O'Brien welcomes Paul Reubens as Pee Wee Herman, actor Donald Faison and musical guests Bon Jovi.

The Tonight Show with Conan O'Brien welcomes actor William Shatner, actress AnnaLynne McCord and a musical performance by the cast of Mary Poppins.

The Tonight Show with Conan O'Brien welcomes actor Tobey Maguire, actor Chris Colfer and musical guest Rickie Lee Jones.

The Tonight Show with Conan O'Brien welcomes actress Jenny McCarthy and comedian Gabriel Iglesias.

The Tonight Show with Conan O'Brien welcomes guest actor John Travolta and guest singer Rod Stewart who also performs.

The Tonight Show with Conan O'Brien welcomes actress Rachel McAdams, actress Mindy Kaling, and musical guest Diane Birch.

The Tonight Show with Conan O'Brien welcomes TV host Howie Mandel, doctor/author Deepak Chopra and musical guest Michael McDonald.

The Tonight Show with Conan O'Brien welcomes actor Josh Brolin, Tillie the Dog Artist and comedian Chad Daniels.

The Tonight Show with Conan O'Brien welcomes rapper Snoop Dogg, movie legend Carl Reiner and a musical performance by Snoop Dogg.

The Tonight Show with Conan O'Brien welcomes actor Ben Stiller, Top Chef winner Michael Voltaggio, and musical guests 30 Seconds To Mars.

The Tonight Show with Conan O'Brien welcomes actor Zach Braff, adventurer Bear Grylls and musical guest Tony Bennett.

The Tonight Show with Conan O'Brien welcomes actor Tom Arnold, actress Cheryl Hines and musical guest Adam Lambert. Plus, Tuning In Late To The News...

The Tonight Show with Conan O'Brien welcomes actress Megan Mullally, TV personalities Mike "The Situation" Sorrentino and Nicole "Snooki" Polizzi,...

The Tonight Show with Conan O'Brien welcomes TV show host Wanda Sykes, director James Cameron and stand-up comedian Myq Kaplan performs.

The Tonight Show with Conan O'Brien welcomes guests actor John Krasinski, molecular mixologist Claire Smith, and a musical performance by Robin...

The Tonight Show with Conan O'Brien welcomes guests actor Sam Worthington, animal expert Nigel Marven, and a musical performance by Foreigner.

The Tonight Show with Conan O'Brien welcomes guests actress Christina Applegate, journalist David Gregory, and a musical performance by Silversun...

The Tonight Show with Conan O'Brien welcomes guests professional cyclist Lance Armstrong, TV show host Carson Daly, and a musical performance by Kid...

The Tonight Show with Conan O'Brien welcomes guests professional basketball player Derek Fisher.

The Tonight Show with Conan O'Brien welcomes actor Ethan Hawke, comic Patton Oswalt and musical guest Katharine McPhee. Plus, a new installment of In...

The Tonight Show with Conan O'Brien welcomes guests actress Queen Latifah, actor Chris Pratt, and comic Juston McKinney. Also, Tuning In Late To The...

The Tonight Show with Conan O'Brien welcomes actor Matthew Broderick, actress Robin Tunney and musical guest Ke$ha. Also, new Celebrity Surveys!

The Tonight Show with Conan O'Brien welcomes actor Jackie Chan, actress Emily Blunt and musical guest Jencarlos. Also, new Audience Plugs.

The Tonight Show with Conan O'Brien welcomes actor Michael Cera, actor and comedian Aziz Ansari and musical guests OK Go. Plus, another Black Thing...

The Tonight Show with Conan O'Brien welcomes actor Gary Oldman, actor Dax Shepard and musical guests Vampire Weekend. Also, a new gala of The Tonight...

The Tonight Show with Conan O'Brien welcomes journalist Tom Brokaw, actor Zachary Levi and musical guest Rosanne Cash. Plus, a special guest helps...

The Tonight Show with Conan O'Brien welcomes actor Ricky Gervais, actress Bryce Dallas Howard, plus a performance by comic Whitney Cummings. Also, a...

The Tonight Show with Conan O'Brien welcomes guests actor Rob Lowe, actress Jane Krakowski, and a musical performance by Hilary Hahn.

The Tonight Show with Conan O'Brien welcomes guests actor Jeff Bridges, actress Mary Lynn Rajskub, and a musical performance by Lifehouse.

The Tonight Show with Conan O'Brien welcomes movie director Martin Scorsese, actor Colin Firth and KOOZA - a Performance from Cirque du Soleil. Plus,...

The Tonight Show with Conan O'Brien welcomes director Quentin Tarantino, actor Paul Bettany and musical guests Spoon.

The Tonight Show with Conan O'Brien welcomes actor Adam Sandler, actor Joel McHale and musical guest Joss Stone.

The Tonight Show with Conan O'Brien welcomes actor Robin Williams and musical guest Barry Manilow.

The Tonight Show with Conan O'Brien welcomes actor Tom Hanks and actor Will Ferrell. This is the Final Episode with Conan, Tom and Will were his...