Armed with her sharp wit and curiosity, Chelsea Handler hosts a groundbreaking talk show full of famous faces, big ideas and mind-blowing adventures.

She's biting, she's brassy, and she's back. Host Chelsea Handler returns with season two of her convention-defying talk show, switching to an hourly,...

Melissa McCarthy and Chelsea recall the rocky road to show biz success. Van Jones slams Trump's recklessness and nepotism. With the "Nobodies" cast.

Chelsea talks resilient women with Charlize Theron, civic engagement with Rep. Linda Sánchez and "the French Donald Trump" with voters in...

Tracee Ellis Ross, Aisha Tyler and Rosario Dawson join Chelsea to scorch Trump's first 100 days in office. Sen. Cory Booker urges political integrity.

Jim Parsons, Rashida Jones, Gaby Hoffmann and Mary McCormack celebrate teachers who impacted their lives. With former Education Secretary John King.

Chelsea quizzes “Guardians of the Galaxy” star Chris Pratt. Amy Schumer, Goldie Hawn and Wanda Sykes play a guessing game. Plus, Rep....

Leah Remini dissects the perils of leaving Scientology, Geoffrey Rush talks Einstein and acting with monkeys, and Danny McBride riffs on movie aliens.

Priyanka Chopra discusses "Baywatch" and self-esteem. Anthony Anderson reflects on racial identity. Sen. Elizabeth Warren champions higher wages.

Sen. Al Franken brings his humor to Congress. Sarah Silverman stands up for women's health issues. Plus, Thomas Middleditch on global warming.

Chelsea gives English etiquette a whirl, goes boating with Eddie Izzard, scrums with a pro rugby team and hits the pub to gauge opinions about Brexit.

Salma Hayek Pinault talks massage and marriage. CNN's Don Lemon discusses truth in journalism. Jerrod Carmichael gets real about the N-word.

Alison Brie and Betty Gilpin dish on wrestling training for "GLOW." Elisabeth Moss ponders real-life echoes of "The Handmaid's Tale." With Janet Mock.

NFL stars Russell Wilson and Kurt Warner, gymnast Aly Raisman and boxer Laila Ali reflect on competing, performance nerves and reinventing themselves.

Chelsea quizzes Harry Styles, chats with singer Rita Ora and talks "Game of Thrones" sexual taboos with John Bradley. With "Pod Save America" hosts.

Actress Cara Delevingne works to empower girls, tech leaders weigh in on cutting-edge automation, and Garbiñe Muguruza savors her big...

Kate Beckinsale, Jill Soloway and Niecy Nash extol diversity in showbiz. Congressmen Ted Lieu and Eric Swalwell discuss immigration and impeachment.

Chelsea discusses Indian culture with actress Freida Pinto, haggles in a Mumbai market with Vikas Khanna, meets a guru and shakes it Bollywood-style.

Reese Witherspoon talks about her new movie and becoming a producer. Kathy Bates discusses "Disjointed" and medical marijuana. With Dan Rather.

James Corden chats musicals and public nudity, Bella Thorne hopes to inspire the next generation, and Sen. Kirsten Gillibrand addresses gun violence.

Jessica Biel gets real about motherhood. Chelsea kayaks with Abbi Jacobson and Ilana Glazer. With S.E. Cupp, Evan McMullin and Andrea Savage.

Emma Stone and Billie Jean King talk “Battle of the Sexes.” Justin Hartley reflects on his Hollywood success. Plus, grassroots politician...

The NFL's Reggie Bush and activist DeRay Mckesson discuss athletes' defiant response to Trump. Maggie Gyllenhaal talks "The Deuce." Plus, Macklemore.

Kevin Hart and the Plastic Cup Boyz joke about comedy. Activists Kris Brown and Igor Volsky voice an urgent plea for gun control. Jackie Chan sings.

Dennis Quaid steps up for hurricane relief, Nancy Pelosi extols women's surging political clout, and Chrissy Metz mulls the impact of "This Is Us."

Jennifer Garner, Rob Riggle, Regina King, Mary McCormack and Dan Savage discuss their roots, patriotism, religion and modem America's complexities.

Gwen Stefani shares her love of Christmas music. Justice Bridget McCormack and activist Jason Kander talk the U.S. court system and voter suppression.

Chelsea talks precocious kids with Jim Parsons, quizzes Will Ferrell and Mark Wahlberg and gets some down-and-dirty workplace sensitivity training.

Lea Michele chats stage fright, karaoke and turkey. CNN's Bill Weir details the plight of post-hurricane Puerto Rico. Plus, a baked spelling bee.

Kerry Washington and her "Scandal" co-stars talk sexual harassment and real-life political bombshells. A pro fixer shares the secrets of good spin.

Former senator Barbara Boxer hails women's growing political clout. Journalist Ronan Farrow digs into the toxic consequences of sexual assault.

Wiz Khalifa, Jill Scott, Shania Twain and Imagine Dragons frontman Dan Reynolds open up about inspiration, success and the emotional power of music.